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Article

Biological activity of a genetically modified BMP-2 variant with inhibitory activity.

Head & face medicine - 2 Feb 2009

Klammert Uwe, Nickel Joachim, Würzler Kristian, Klingelhöffer Christoph, Sebald Walter, Kübler Alexander C, Reuther Tobias

Abstract excerpt

BACKGROUND: Alterations of the binding epitopes of bone morphogenetic protein-2 (BMP-2) lead to a modified interaction with the ectodomains of BMP receptors. In the present study the biological effect of a BMP-2 double mutant with antagonistic activity was evaluated in vivo. METHODS: Equine-derived collagenous carriers were loaded with recombinant human BMP-2 (rhBMP-2) in a well-known dose to provide an...

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Source

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Identifiers

PMID: 19187528
DOI: 10.1186/1746-160X-5-6
PMCID: PMC2646720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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