Synergistic Effect of Bone Morphogenetic Proteins 2 and 7 by ex Vivo Gene Therapy in a Rat Spinal Fusion Model

Abstract excerpt

BACKGROUND: Previous studies have suggested that the co-expression of two different bone morphogenetic protein (BMP) genes can result in the production of heterodimeric BMPs that may be more potent than homodimers. In this study, combined BMP-2 and BMP-7 gene transfer was performed ex vivo to compare the resulting new bone formation with that of single-BMP gene transfer in a rat spinal fusion model. METHODS:...

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