Article
[Evaluation of the osteoinductive potential of genetically modified BMP-2 variants].
Mund-, Kiefer- und Gesichtschirurgie : MKG - 1 Mar 2004
Würzler K K, Emmert J, Eichelsbacher F, Kübler N R, Sebald W, Reuther J F
Abstract excerpt
BACKGROUND: The alteration of the N-terminal amino acid sequence of BMP-2 allows modification of heparin binding of the new protein. This leads to a change in the local retention time at the site of implantation. Mutants with increased (T3, T4) and with no binding (EHBMP-2) to heparin were assessed for their osteoinductivity in vivo and compared with the wild type BMP-2. METHODS: Cylindrical collagenous carriers...
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