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Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle

21 Sept 2015

Abstract excerpt

Large segmental defects in bone fail to heal and remain a clinical problem. Muscle is highly osteogenic, and preliminary data suggest that autologous muscle tissue expressing bone morphogenetic protein-2 (BMP-2) efficiently heals critical size defects in rats. Translation into possible human clinical trials requires, inter alia, demonstration of efficacy in a large animal, such as the sheep. Scale-up is fraught...

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PMID: 26388615
DOI: 10.22203/ecm.v030a09

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