Use of Recombinant Human Bone Morphogenetic Protein-2 in Spinal Fusion Applications

Abstract excerpt

Bone morphogenetic proteins (BMPs) have been the subject of considerable research for several decades. The academic chronicle began in 1965 with Dr. Marshall Urist’s discovery of osteoinductive activity within demineralized bone protein extracts, and continued with his later identification of the active molecules as bone morphogenetic proteins. 23,24 This was followed in 1988 by the isolation of an individual...

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