Article
[Comparison of the osteogenic activity of bone morphogenetic protein (BMP) mutants].
Mund-, Kiefer- und Gesichtschirurgie : MKG - 1 Nov 2005
Depprich R, Handschel J, Sebald W, Kübler N R, Würzler K K
Abstract excerpt
BACKGROUND: Modification of the heparin binding site by alteration of the amino acid sequence of bone morphogenetic protein-2 (BMP-2) results in a change in the local retention time. The purpose of this study was to compare the osteogenic activity of T3 and T4, two mutants with increased binding capacity to heparin, and B2GDF-5 a mutant resulting from the fusion of the n-terminal amino acid sequence of BMP-2 and...
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