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Article

Structural basis for recognition of diubiquitins by NEMO.

Molecular cell - 13 Mar 2009

Lo Yu-Chih, Lin Su-Chang, Rospigliosi Carla C, Conze Dietrich B, Wu Chuan-Jin, Ashwell Jonathan D, Eliezer David, Wu Hao

Abstract excerpt

NEMO is the regulatory subunit of the IkappaB kinase (IKK) in NF-kappaB activation, and its CC2-LZ region interacts with Lys63 (K63)-linked polyubiquitin to recruit IKK to receptor signaling complexes. In vitro, CC2-LZ also interacts with tandem diubiquitin. Here we report the crystal structure of CC2-LZ with two dimeric coiled coils representing CC2 and LZ, respectively. Surprisingly, mutagenesis and nuclear...

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Identifiers

PMID: 19185524
DOI: 10.1016/j.molcel.2009.01.012
PMCID: PMC2749619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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