Article
Aberrant activation of interleukin-9 receptor and downstream Stat3/5 in primary T-cell lymphomas in vivo in susceptible B6 and resistant C3H mice.
In vivo (Athens, Greece) - 1 Jan 2000
Shang Yi, Kakinuma Shizuko, Amasaki Yoshiko, Nishimura Mayumi, Kobayashi Yoshiro, Shimada Yoshiya
Abstract excerpt
BACKGROUND: Interleukin (IL)-2 family cytokine-mediated signal transduction plays important roles not only in normal development but also in the malignant transformation of lymphoid cells. However, little is known about the status of receptor activation and downstream signal transduction in primary lymphomas in vivo. MATERIALS AND METHODS: Primary T-cell lymphomas (TL) of mice were induced by X-ray irradiation....
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