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Article

STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells.

Cancer research - 15 Jul 2000

Demoulin J B, Uyttenhove C, Lejeune D, Mui A, Groner B, Renauld J C

Abstract excerpt

Interleukin-9 (IL-9) is a growth factor for T cells and various hematopoietic and lymphoid tumor cells. IL-9 signaling involves activation of Janus kinase (JAK)1 and JAK3 kinases, and signal transducer and activator of transcription (STAT)1, STAT3 and STAT5. Using a dominant negative form of STAT5 (STAT5delta), we demonstrated that this factor is an important mediator of IL-9-dependent Ba/F3 cell growth. Mutation...

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Source

Identifiers

PMID: 10919676

Genes

JAK1
JAK3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells.PMID 10919676Read ↗

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