Synthesis of thiamine in Salmonella typhimurium independent of the purF function.

Abstract excerpt

In Salmonella typhimurium, the first five steps in purine biosynthesis also serve as the first steps in the biosynthesis of the pyrimidine moiety of thiamine (vitamin B1). Strains with null mutations of the first gene of purine-thiamine synthesis (purF) can, under some circumstances, grow without thiamine. This suggests the existence of an alternative pathway to thiamine that can function without the purF...

Topics

• Adenine
• Blotting, Southern
• Chromosome Deletion
• Chromosome Mapping
• Genetic Variation
• Histidine
• Kinetics
• Mutation
• Pantothenic Acid
• Phenotype
• Purines
• Ribonucleotides