Article
Evidence for a new, oxygen-regulated biosynthetic pathway for the pyrimidine moiety of thiamine in Salmonella typhimurium.
Journal of bacteriology - 1 Mar 1992
Downs D M
Abstract excerpt
The synthesis of the pyrimidine moiety of thiamine (vitamin B1) shares five reactions with the de novo purine biosynthetic pathway. Aminoimidazole ribotide (AIR) is the last common intermediate before the two pathways diverge. Evidence for the existence of a new pathway to the pyrimidine which bypasses the de novo purine biosynthetic pathway is reported here. This pathway is only expressed under anaerobic growth...
Topics
- Anaerobiosis
- Aspartic Acid
- Gene Expression Regulation, Bacterial
- Mutation
- Pantothenic Acid
- Pyrimidines
- Ribonucleotides
- Salmonella typhimurium
- Thiamine