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Article

Mutations in the tryptophan operon allow PurF-independent thiamine synthesis by altering flux in vivo.

Journal of bacteriology - 1 Feb 2008

Ramos Itzel, Vivas E I, Downs D M

Abstract excerpt

Phosphoribosyl amine (PRA) is an intermediate in purine biosynthesis and also required for thiamine biosynthesis in Salmonella enterica. PRA is normally synthesized by phosphoribosyl pyrophosphate amidotransferase, a high-turnover enzyme of the purine biosynthetic pathway encoded by purF. However, PurF-independent PRA synthesis has been observed in strains having different genetic backgrounds and growing under...

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Identifiers

PMID: 17557816
DOI: 10.1128/JB.00582-07
PMCID: PMC2223571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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