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Article

Low-dose fractionated radiation potentiates the effects of Paclitaxel in wild-type and mutant p53 head and neck tumor cell lines.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2003

Dey Swatee, Spring Paul M, Arnold Suzanne, Valentino Joseph, Chendil Damodaran, Regine William F, Mohiuddin Mohammed, Ahmed Mansoor M

Abstract excerpt

This study was designed to: (a) evaluate the induction of hyper-radiation sensitivity (HRS), a phenomenon observed at low doses of radiation (<1 Gy); (b) compare the potentiating effects of single dose radiation (2 Gy) versus the effect of low-dose fractionated radiation (LDFRT; <1 Gy) on Paclitaxel; and (c) understand the molecular mechanism of LDFRT-mediated chemo-potentiating effects, in wild-type p53 SCC-61...

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Share to Antineoplastic Agents, Phytogenic
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Radiation

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Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 12684432

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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