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Article

Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant.

Biochemistry - 24 Feb 2009

Garvey Edward P, Schwartz Benjamin, Gartland Margaret J, Lang Scott, Halsey Wendy, Sathe Ganesh, Carter H Luke, Weaver Kurt L

Abstract excerpt

Two-metal binding HIV-1 integrase inhibitors (INIs) are potent inhibitors of HIV-1 in vitro and in patients. We report here for the first time the kinetics of inhibition of integrase-catalyzed strand transfer. First, the IC(50) values for each of six structurally distinct INIs decreased when a pr...

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PMID: 19178153
DOI: 10.1021/bi802141y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19178153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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