Article
In Vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor.
Antimicrobial agents and chemotherapy - 1 Feb 2011
Kobayashi Masanori, Yoshinaga Tomokazu, Seki Takahiro, Wakasa-Morimoto Chiaki, Brown Kevin W, Ferris Robert, Foster Scott A, Hazen Richard J, Miki Shigeru, Suyama-Kagitani Akemi, Kawauchi-Miki Shinobu, Taishi Teruhiko, Kawasuji Takashi, Johns Brian A, Underwood Mark R, Garvey Edward P, Sato Akihiko, Fujiwara Tamio
Abstract excerpt
S/GSK1349572 is a next-generation HIV integrase (IN) inhibitor designed to deliver potent antiviral activity with a low-milligram once-daily dose requiring no pharmacokinetic (PK) booster. In addition, S/GSK1349572 demonstrates activity against clinically relevant IN mutant viruses and has potential for a high genetic barrier to resistance. S/GSK1349572 is a two-metal-binding HIV integrase strand transfer...
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