Article
Physical trapping of HIV-1 synaptic complex by different structural classes of integrase strand transfer inhibitors.
Biochemistry - 28 Sept 2010
Pandey Krishan K, Bera Sibes, Vora Ajaykumar C, Grandgenett Duane P
Abstract excerpt
Raltegravir is an FDA approved inhibitor directed against human immunodeficiency virus type 1 (HIV-1) integrase (IN). In this study, we investigated the mechanisms associated with multiple strand transfer inhibitors capable of inhibiting concerted integration by HIV-1 IN. The results show raltegravir, elvitegravir, MK-2048, RDS 1997, and RDS 2197 all appear to encompass a common inhibitory mechanism by modifying...
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