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Article

Biochemical Analysis of HIV-1 Integrase Variants Resistant to Strand Transfer Inhibitors

25 Jun 2008

Abstract excerpt

In this study, eight different HIV-1 integrase proteins containing mutations observed in strand transfer inhibitor-resistant viruses were expressed, purified, and used for detailed enzymatic analyses. All the variants examined were impaired for strand transfer activity compared with the wild type enzyme, with relative catalytic efficiencies (k(p)/K(m)) ranging from 0.6 to 50% of wild type. The origin of the...

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PMID: 18577511
DOI: 10.1074/jbc.m804213200

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