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Article

Aberrant Promoter Methylation of Sparc in Ovarian Cancer

1 Feb 2009

Abstract excerpt

Epigenetic silencing of tumor suppressor genes is a new focus of investigation in the generation and proliferation of carcinomas. Secreted protein acidic and rich in cysteine (SPARC) is reportedly detrimental to the growth of ovarian cancer cells and has been shown to be epigenetically silenced in several cancers. We hypothesized that SPARC is downregulated in ovarian cancer through aberrant promoter...

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Identifiers

PMID: 19177197
DOI: 10.1593/neo.81146

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Related research

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Research trail→

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Aberrant Promoter Methylation of Sparc in Ovarian CancerPMID 19177197Read ↗

Aberrant methylation of the SPARC gene promoter and its clinical implication in gastric cancerSemantic proximity Read ↗

Overexpression of SPARC protein contrasts with its transcriptional silencing by aberrant hypermethylation of SPARC CpG-rich region in endometrial carcinomaSemantic proximity Read ↗

Frequent inactivation of SPARC by promoter hypermethylation in colon cancersSemantic proximity Read ↗

SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2′deoxycytidine to increase SPARC expression and improve therapy responseSemantic proximity Read ↗

Associations of tumor suppressor SPARCL1 with cancer progression and prognosisSemantic proximity Read ↗

Downregulation of SPARC expression decreases gastric cancer cellular invasion and survivalSemantic proximity Read ↗

Methylation of the SPARC gene promoter and its clinical implication in pancreatic cancerSemantic proximity Read ↗

Frequent inactivation of hSRBC in ovarian cancers by promoter CpG island hypermethylation.Semantic proximity Read ↗

SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signalingSemantic proximity Read ↗

Clinical significance of SPARC gene expression in patients with gastric cancerSemantic proximity Read ↗

SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system.Semantic proximity Read ↗

Inhibition of endogenous SPARC enhances pancreatic cancer cell growth: modulation by FGFR1-III isoform expression.Semantic proximity Read ↗

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