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Article

SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system.

Molecular biology of the cell - 1 Oct 2003

Schiemann Barbara J, Neil Jason R, Schiemann William P

Abstract excerpt

Secreted protein, acidic and rich in cysteine (SPARC) is a multifunctional secreted protein that regulates cell-cell and cell-matrix interactions, leading to alterations in cell adhesion, motility, and proliferation. Although SPARC is expressed in epithelial cells, its ability to regulate epithelial cell growth remains largely unknown. We show herein that SPARC strongly inhibited DNA synthesis in transforming...

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Source

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Identifiers

PMID: 14517312
DOI: 10.1091/mbc.e03-01-0001
PMCID: PMC206993

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system.PMID 14517312Read ↗

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