Article
Lack of association between TGF-beta-1 genotypes and microalbuminuria in essential hypertensive men.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jun 2009
Dell'Omo Giulia, Penno Giuseppe, Pucci Laura, Lucchesi Daniela, Del Prato Stefano, Pedrinelli Roberto
Abstract excerpt
BACKGROUND: Polymorphisms within the gene for transforming growth factor (TGF)-beta-1, a pro-fibrogenic cytokine pathophysiologically involved in hypertension and hypertensive target damage, might modulate the biological activity of the encoded protein. Through that mechanism, they might contribute to microalbuminuria, a marker of subclinical renal damage and a correlate of systemic inflammation and endothelial...
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