Article
Conservation and dispersion of sequence and function in fungal TRK potassium transporters: focus on Candida albicans.
FEMS yeast research - 1 Mar 2009
Miranda Manuel, Bashi Esther, Vylkova Slavena, Edgerton Mira, Slayman Clifford, Rivetta Alberto
Abstract excerpt
TRK proteins - essential potassium (K(+)) transporters in fungi and bacteria, as well as in plants - are generally absent from animal cells, which makes them potential targets for selective drug action. Indeed, in the human pathogen Candida albicans, the single TRK isoform (CaTrk1p) has recently been demonstrated to be required for activity of histidine-rich salivary antimicrobial peptides (histatins). Background...
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