Article
The TRK1 potassium transporter is the critical effector for killing of Candida albicans by the cationic protein, Histatin 5.
The Journal of biological chemistry - 31 Dec 2004
Baev Didi, Rivetta Alberto, Vylkova Slavena, Sun Jianing N, Zeng Ge-Fei, Slayman Clifford L, Edgerton Mira
Abstract excerpt
The principal feature of killing of Candida albicans and other pathogenic fungi by the catonic protein Histatin 5 (Hst 5) is loss of cytoplasmic small molecules and ions, including ATP and K(+), which can be blocked by the anion channel inhibitor 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid. We constructed C. albicans strains expressing one, two, or three copies of the TRK1 gene in order to investigate...
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