Article
High prevalence of preinvasive lesions adjacent to BRCA1/2-associated breast cancers.
Cancer prevention research (Philadelphia, Pa.) - 1 Feb 2009
Arun Banu, Vogel Kristen J, Lopez Adriana, Hernandez Mike, Atchley Deann, Broglio Kristine R, Amos Christopher I, Meric-Bernstam Funda, Kuerer Henry, Hortobagyi Gabriel N, Albarracin Constance T
Abstract excerpt
Mutations in BRCA1 and BRCA2 increase a woman's lifetime risk of developing breast cancer by 43% to 84%. It was originally postulated that BRCA1/2-associated breast cancers develop more rapidly than sporadic cancers and may lack preinvasive lesions. More recent studies have found preinvasive lesions in prophylactic mastectomy specimens from mutation carriers; however, there is little information on the presence...
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