Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High prevalence of premalignant lesions in prophylactically removed breasts from women at hereditary risk for breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jan 2003

Hoogerbrugge N, Bult P, de Widt-Levert L M, Beex L V, Kiemeney L A, Ligtenberg M J L, Massuger L F, Boetes C, Manders P, Brunner H G

Abstract excerpt

PURPOSE: Women with a hereditary predisposition for breast cancer have an extremely high risk of developing invasive breast carcinoma, and many women consider prophylactic mastectomy to avoid this risk. The use of prophylactic mastectomy is still debated. Identification of frequent premalignant lesions in mastectomy specimens would support the preventive concept of prophylactic mastectomy. PATIENTS AND METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Distribution
Share to Carcinoma in Situ

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Intraductal, Noninfiltrating

Share to Hyperplasia

Share to Mastectomy

Share to Multivariate Analysis

Share to Precancerous Conditions

Share to ROC Curve

Source

Identifiers

PMID: 12506168
DOI: 10.1200/JCO.2003.02.137

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High prevalence of premalignant lesions in prophylactically removed breasts from women at hereditary risk for breast cancer.PMID 12506168Read ↗

Epithelial lesions in prophylactic mastectomy specimens from women with BRCA mutations.Semantic proximity Read ↗

Numerous high-risk epithelial lesions in familial breast cancer.Semantic proximity Read ↗

Histopathological findings and follow-up after prophylactic mastectomy and immediate breast reconstruction in 100 women from families with hereditary breast cancer.Semantic proximity Read ↗

Prophylactic mastectomy in familial breast carcinoma. What do the pathologic findings learn us?Semantic proximity Read ↗

High rate of occult cancer found in prophylactic mastectomy specimens despite thorough presurgical assessment with MRI and ultrasound: findings from the Hereditary Breast and Ovarian Cancer Registration 2016 in Japan.Semantic proximity Read ↗

Low prevalence of (pre) malignant lesions in the breast and high prevalence in the ovary and Fallopian tube in women at hereditary high risk of breast and ovarian cancer.Semantic proximity Read ↗

Lobulitis is a frequent finding in prophylactically removed breast tissue from women at hereditary high risk of breast cancer.Semantic proximity Read ↗

Spectrum of histopathologic findings in risk-reducing bilateral prophylactic mastectomy in patients with and without BRCA mutations.Semantic proximity Read ↗

High prevalence of preinvasive lesions adjacent to BRCA1/2-associated breast cancers.Semantic proximity Read ↗

Prevalence of pre-malignant and malignant lesions in prophylactic mastectomy specimens of BRCA1 mutation carriers: comparison with a control group.Semantic proximity Read ↗

Pathologic characteristics of breast parenchyma in patients with hereditary breast carcinoma, including BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

Biological features of premalignant disease in the human breast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.