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Article

Direct interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogen.

Genes & development - 15 Jan 2009

Goodman Andrew L, Merighi Massimo, Hyodo Mamoru, Ventre Isabelle, Filloux Alain, Lory Stephen

Abstract excerpt

The genome of the opportunistic pathogen Pseudomonas aeruginosa encodes over 60 two-component sensor kinases and uses several (including RetS and GacS) to reciprocally regulate the production of virulence factors involved in the development of acute or chronic infections. We demonstrate that RetS modulates the phosphorylation state of GacS by a direct and specific interaction between these two membrane-bound...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19171785
DOI: 10.1101/gad.1739009
PMCID: PMC2648536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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