A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence.

doi:10.1186/1471-2164-12-437

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Article

A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence.

BMC genomics - 31 Aug 2011

Goldová Jana, Ulrych Aleš, Hercík Kamil, Branny Pavel

Abstract excerpt

BACKGROUND: The genome of Pseudomonas aeruginosa contains at least three genes encoding eukaryotic-type Ser/Thr protein kinases, one of which, ppkA, has been implicated in P. aeruginosa virulence. Together with the adjacent pppA phosphatase gene, they belong to the type VI secretion system (H1-T6SS) locus, which is important for bacterial pathogenesis. To determine the biological function of this protein pair, we...

Topics

Animals
Bacterial Proteins
Cell Line
Gene Deletion
Gene Expression Regulation, Bacterial
Genetic Complementation Test
Lactuca
Macrophages
Mice
Microbial Viability
Oligonucleotide Array Sequence Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligopeptides

Oxidative Stress

Phenotype

Protein Serine-Threonine Kinases

Pseudomonas aeruginosa

RNA, Bacterial

Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 21880152
DOI: 10.1186/1471-2164-12-437
PMCID: PMC3224232

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