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Article

Seven-year follow-up of a juvenile female with papillary thyroid carcinoma with poor outcome, BRAF mutation and loss of expression of iodine-metabolizing genes.

Arquivos brasileiros de endocrinologia e metabologia - 1 Nov 2008

Oler Gisele, Nakabashi Claudia D, Biscolla Rosa Paula M, Cerutti Janete M

Abstract excerpt

BACKGROUND: Recent studies reported that BRAF V600E mutation, the most prevalent genetic event found in papillary thyroid carcinoma, is an independent poor prognostic marker. Additionally, it correlates with a less differentiated tumor stage due to reduced expression of key genes involved in iodi...

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Share to Carcinoma, Papillary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Iodine

Share to Proto-Oncogene Proteins B-raf

Share to Receptors, Thyrotropin

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Source

Identifiers

PMID: 19169486
DOI: 10.1590/s0004-27302008000800017

Genes

BRAF
TSHR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19169486-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Seven-year follow-up of a juvenile female with papillary thyroid carcinoma with poor outcome, BRAF mutation and loss of expression of iodine-metabolizing genes.PMID 19169486Read ↗

BRAF V600E and decreased NIS and TPO expression are associated with aggressiveness of a subgroup of papillary thyroid microcarcinoma.Semantic proximity Read ↗

High prevalence of BRAF mutation in a Brazilian cohort of patients with sporadic papillary thyroid carcinomas: correlation with more aggressive phenotype and decreased expression of iodide-metabolizing genes.Semantic proximity Read ↗

Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.Semantic proximity Read ↗

The Clinical Significance of BRAFV600E Mutations in Pediatric Papillary Thyroid CarcinomasSemantic proximity Read ↗

The BRAF V600E mutation is a predictor of the effect of radioiodine therapy in papillary thyroid cancerSemantic proximity Read ↗

Expression of iodine metabolism genes in human thyroid tissues: evidence for age and BRAFV600E mutation dependency.Semantic proximity Read ↗

The clinical significance of BRAFV600E mutations in pediatric papillary thyroid carcinomas.Semantic proximity Read ↗

BRAF Mutations in Papillary Thyroid Carcinomas Inhibit Genes Involved in Iodine MetabolismSemantic proximity Read ↗

Juvenile differentiated thyroid carcinoma and the role of radioiodine in its treatment: a qualitative reviewSemantic proximity Read ↗

An Animal Model Further Uncovers the Role of Mutant BrafV600E during Papillary Thyroid Cancer Development.Semantic proximity Read ↗

Thyrotropin signaling confers more aggressive features with higher genomic instability on BRAF(V600E)-induced thyroid tumors in a mouse model.Semantic proximity Read ↗

BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas.Semantic proximity Read ↗

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