Article
Low prevalence of Gs alpha mutations in śomatotroph adenomas of children and adolescents.
Cancer genetics and cytogenetics - 15 Apr 2006
Metzler Markus, Luedecke Dieter K, Saeger Wolfgang, Grueters Annette, Haberl Hannes, Kiess Wieland, Repp Reinald, Rascher Wolfgang, Doetsch Joerg
Abstract excerpt
Mutations in the gene coding for the alpha-subunit of the heterotrimeric stimulatory G protein Gs are the most frequently identified molecular events in the development of somatotroph adenomas in adults. In children and adolescents, somatotroph adenomas are rare, and only two cases with the Gs alpha mutation have been reported so far. In this study, we therefore investigated the prevalence of activating Gs alpha...
Topics
- Adolescent
- Adult
- Age Distribution
- Child
- Exons
- Female
- GTP-Binding Protein alpha Subunits, Gs
- Growth Hormone-Secreting Pituitary Adenoma
- Humans
- Male
- Mutation