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Article

Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant.

Biological psychiatry - 1 Aug 2009

Mirakhur Ajay, Moorhead T William J, Stanfield Andrew C, McKirdy James, Sussmann Jessika E D, Hall Jeremy, Lawrie Stephen M, Johnstone Eve C, McIntosh Andrew M

Abstract excerpt

BACKGROUND: Evidence suggests that structural brain changes occur over time in bipolar disorder but few studies have examined this longitudinally. Additional work implicates brain-derived neurotrophic factor (BDNF) valine (val)(66)methionine (met) variant in these changes. The present study examined longitudinal trends in prefrontal gyrification index (GI) in bipolar disorder and the effect of BDNF genotype....

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Source

Identifiers

PMID: 19167700
DOI: 10.1016/j.biopsych.2008.12.006

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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