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Article

Effects of the brain-derived neurotrophic growth factor val66met variation on hippocampus morphology in bipolar disorder.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2009

Chepenik Lara G, Fredericks Carolyn, Papademetris Xenophon, Spencer Linda, Lacadie Cheryl, Wang Fei, Pittman Brian, Duncan James S, Staib Lawrence H, Duman Ronald S, Gelernter Joel, Blumberg Hilary P

Abstract excerpt

Histological and behavioral research in bipolar disorder (BD) implicates structural abnormalities in the hippocampus. Brain-derived neurotrophic growth factor (BDNF) protein is associated with hippocampal development and plasticity, and in mood disorder pathophysiology. We tested the hypotheses that both the BDNF val66met polymorphism and BD diagnosis are associated with decreased hippocampus volume, and that...

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Identifiers

PMID: 18704093
DOI: 10.1038/npp.2008.107
PMCID: PMC2837582

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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