Article
Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia.
The American journal of psychiatry - 1 Dec 2007
Ho Beng-Choon, Andreasen Nancy C, Dawson Jeffrey D, Wassink Thomas H
Abstract excerpt
OBJECTIVE: Factors underlying progressive brain volume changes in schizophrenia remain poorly understood. The authors investigated whether a gene polymorphism influencing neuroplasticity may contribute to longitudinal brain volume alterations. METHOD: High-resolution magnetic resonance (MR) images of the whole brain were obtained for 119 patients with recent-onset schizophrenia spectrum disorders. Changes in...
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