Article
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.
Cancer cell - 1 Nov 2006
Holmquist-Mengelbier Linda, Fredlund Erik, Löfstedt Tobias, Noguera Rosa, Navarro Samuel, Nilsson Helén, Pietras Alexander, Vallon-Christersson Johan, Borg Ake, Gradin Katarina, Poellinger Lorenz, Påhlman Sven
Abstract excerpt
In neuroblastoma specimens, HIF-2alpha but not HIF-1alpha is strongly expressed in well-vascularized areas. In vitro, HIF-2alpha protein was stabilized at 5% O2 (resembling end capillary oxygen conditions) and, in contrast to the low HIF-1alpha activity at this oxygen level, actively transcribed...
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