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Article

Deficient mismatch repair system in patients with sporadic advanced colorectal cancer

1 Jan 2009

Abstract excerpt

A deficient mismatch repair system (dMMR) is present in 10-20% of patients with sporadic colorectal cancer (CRC) and is associated with a favourable prognosis in early stage disease. Data on patients with advanced disease are scarce. Our aim was to investigate the incidence and outcome of sporadic dMMR in advanced CRC. Data were collected from a phase III study in 820 advanced CRC patients. Expression of mismatch...

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PMID: 19165197
DOI: 10.1038/sj.bjc.6604867

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