Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficient mismatch repair phenotype is a prognostic factor for colorectal cancer in elderly patients.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Mar 2013

Aparicio Thomas, Schischmanoff Olivier, Poupardin Cecile, Soufir Nadem, Angelakov Celine, Barrat Christophe, Levy Vincent, Choudat Laurence, Cucherousset Joel, Boubaya Marouane, Lagorce Christine, Guetz Gaetan Des, Wind Philippe, Benamouzig Robert

Abstract excerpt

OBJECTIVE: About 15% of colorectal adenocarcinomas have a deficient DNA mismatch repair phenotype. The frequency of deficient DNA mismatch repair tumours increases with age due to the hypermethylation of hMLH1 promoter. The study aimed to determine the prognostic value of deficient DNA mismatch repair phenotype in elderly patients. DESIGN: Mismatch repair phenotype was retrospectively determined by molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Age Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Disease-Free Survival

Share to DNA Methylation

Share to DNA Mismatch Repair

Share to Microsatellite Instability

Share to Prognosis

Source

Identifiers

PMID: 23102497
DOI: 10.1016/j.dld.2012.09.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficient mismatch repair phenotype is a prognostic factor for colorectal cancer in elderly patients.PMID 23102497Read ↗

Implications of mismatch repair-deficient status on management of early stage colorectal cancer.Semantic proximity Read ↗

Clinicopathological and molecular characterization of deficient mismatch repair colorectal cancer.Semantic proximity Read ↗

High prevalence of deficient mismatch repair phenotype and the V600E BRAF mutation in elderly patients with colorectal cancer.Semantic proximity Read ↗

Prevalence and clinicopathologic/molecular characteristics of mismatch repair-deficient colorectal cancer in the under-50-year-old Japanese population.Semantic proximity Read ↗

Deficient mismatch repair system in patients with sporadic advanced colorectal cancerSemantic proximity Read ↗

Mismatch repair deficient colorectal cancer in the era of personalized treatment.Semantic proximity Read ↗

Molecular subtypes in early colorectal cancer associated with clinical features and patient prognosis.Semantic proximity Read ↗

Identification of MKI67, TPR , and TCHH Mutations as Prognostic Biomarkers for Patients With Defective Mismatch Repair Colon Cancer Stage II/III.Semantic proximity Read ↗

Age-related incidence of mismatch repair deficiency (dMMR) and its prognostic role in BRAF-mutant colorectal cancerSemantic proximity Read ↗

Mismatch repair system in colorectal cancer. Frequency, cancer phenotype, and follow-up.Semantic proximity Read ↗

Role of Deficient DNA Mismatch Repair Status in Patients With Stage III Colon Cancer Treated With FOLFOX Adjuvant Chemotherapy: A Pooled Analysis From 2 Randomized Clinical Trials.Semantic proximity Read ↗

Role of DNA repair systems in malignant tumor development in the elderly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.