Article
Functional phenotyping and genotyping of circulating tumor cells from patients with castration resistant prostate cancer.
Cancer letters - 18 May 2009
Paris Pamela L, Kobayashi Yasuko, Zhao Qiang, Zeng Wei, Sridharan Shivaranjani, Fan Tina, Adler Howard L, Yera Emmanuel R, Zarrabi M H, Zucker Stanley, Simko Jeffry, Chen Wen-Tien, Rosenberg Jonathan
Abstract excerpt
Circulating tumor cells (CTCs) hold promise for studying advanced prostate cancer. A functional collagen adhesion matrix (CAM) assay was used to enrich CTCs from prostate cancer patients' blood. CAM ingestion and epithelial immuno-staining identified CTCs, which were genotyped using oligonucleotide array comparative genomic hybridization. The highest CTC counts were observed in men with metastatic castration...
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