Article
An improved CTC isolation scheme for pairing with downstream genomics: Demonstrating clinical utility in metastatic prostate, lung and pancreatic cancer.
Cancer letters - 28 Sept 2016
Premasekharan Gayatri, Gilbert Elizabeth, Okimoto Ross A, Hamirani Ashiya, Lindquist Karla J, Ngo Vy T, Roy Ritu, Hough Jeffrey, Edwards Matthew, Paz Rosa, Foye Adam, Sood Riddhi, Copren Kirsten A, Gubens Matthew, Small Eric J, Bivona Trever G, Collisson Eric A, Friedlander Terence W, Paris Pamela L
Abstract excerpt
Improvements in technologies to yield purer circulating tumor cells (CTCs) will enable a broader range of clinical applications. We have previously demonstrated the use of a commercially available cell-adhesion matrix (CAM) assay to capture invasive CTCs (iCTCs). To improve the purity of the isolated iCTCs, here we used fluorescence-activated cell sorting (FACS) in combination with the CAM assay (CAM + FACS). Our...
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