Article
Prevalence and sequence variations of the genes encoding the five antigens included in the novel 5CVMB vaccine covering group B meningococcal disease.
Vaccine - 4 Mar 2009
Jacobsson Susanne, Hedberg Sara Thulin, Mölling Paula, Unemo Magnus, Comanducci Maurizio, Rappuoli Rino, Olcén Per
Abstract excerpt
During the recent years, projects are in progress for designing broad-range non-capsular-based meningococcal vaccines, covering also serogroup B isolates. We have examined three genes encoding antigens (NadA, GNA1030 and GNA2091) included in a novel vaccine, i.e. the 5 Component Vaccine against Meningococcus B (5CVMB), in terms of gene prevalence and sequence variations. These data were combined with the results...
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