Article
Characterization of fHbp, nhba (gna2132), nadA, porA, and sequence type in group B meningococcal case isolates collected in England and Wales during January 2008 and potential coverage of an investigational group B meningococcal vaccine.
Clinical and vaccine immunology : CVI - 1 Jun 2010
Lucidarme Jay, Comanducci Maurizio, Findlow Jamie, Gray Stephen J, Kaczmarski Edward B, Guiver Malcolm, Vallely Pamela J, Oster Philipp, Pizza Mariagrazia, Bambini Stefania, Muzzi Alessandro, Borrow Ray
Abstract excerpt
Invasive disease caused by meningococcal capsular groups A, C, W-135, and Y is now preventable by means of glycoconjugate vaccines that target their respective polysaccharide capsules. The capsule of group B meningococci (MenB) is poorly immunogenic and may induce autoimmunity. Vaccines based on the major immunodominant surface porin, PorA, are effective against clonal epidemics but, thus far, have a limited...
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