Article
Novel meningococcal 4CMenB vaccine antigens - prevalence and polymorphisms of the encoding genes in Neisseria gonorrhoeae.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Sept 2012
Hadad Ronza, Jacobsson Susanne, Pizza Mariagrazia, Rappuoli Rino, Fredlund Hans, Olcén Per, Unemo Magnus
Abstract excerpt
The first cross-protective Neisseria meningitidis vaccine (focus on serogroup B), the protein-based 4 component meningococcus serogroup B (4CMenB), includes the New Zealand outer membrane vesicle and three main genome-derived neisserial antigens (GNAs). These GNAs are fHbp (fused to GNA2091), NHBA (fused to GNA1030) and NadA. In this study, the prevalence and polymorphisms of the nucleotide and amino acid...
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