Article
Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus.
Vaccine - 11 May 2009
Bambini Stefania, Muzzi Alessandro, Olcen Per, Rappuoli Rino, Pizza Mariagrazia, Comanducci Maurizio
Abstract excerpt
With the aim of studying the molecular diversity of the antigens of a new recombinant vaccine against meningococcus serogroup B, the three genes coding for the main vaccine components GNA (Genome-derived Neisseria Antigen) 1870 (fHbp, factor H Binding Protein), GNA1994 (NadA, Neisseria adhesin A) and GNA2132 were sequenced in a panel of 85 strains collected worldwide and selected as representative of the...
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