Article
Cytoplasmic Inter-Subunit Interface Controls Use-Dependence of Thermal Activation of TRPV3 Channel.
International journal of molecular sciences - 16 Aug 2019
Macikova Lucie, Vyklicka Lenka, Barvik Ivan, Sobolevsky Alexander I, Vlachova Viktorie
Abstract excerpt
The vanilloid transient receptor potential channel TRPV3 is a putative molecular thermosensor widely considered to be involved in cutaneous sensation, skin homeostasis, nociception, and pruritus. Repeated stimulation of TRPV3 by high temperatures above 50 °C progressively increases its responses and shifts the activation threshold to physiological temperatures. This use-dependence does not occur in the related...
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