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Article

A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors.

Molecular and cellular biology - 1 Apr 2009

Kawashima Toshiyuki, Bao Ying Chun, Minoshima Yukinori, Nomura Yasushi, Hatori Tomonori, Hori Tetsuya, Fukagawa Tatsuo, Fukada Toshiyuki, Takahashi Noriko, Nosaka Tetsuya, Inoue Makoto, Sato Tomohiro, Kukimoto-Niino Mutsuko, Shirouzu Mikako, Yokoyama Shigeyuki, Kitamura Toshio

Abstract excerpt

In addition to their pleiotropic functions under physiological conditions, transcription factors STAT3 and STAT5 also have oncogenic activities, but how activated STATs are transported to the nucleus has not been fully understood. Here we show that an MgcRacGAP mutant lacking its nuclear localizi...

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Source

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Identifiers

PMID: 19158271
DOI: 10.1128/MCB.01423-08
PMCID: PMC2655612

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19158271-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors.PMID 19158271Read ↗

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