Article
New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase.
The Journal of biological chemistry - 3 Apr 2009
Unno Hideaki, Yamashita Satoshi, Ikeda Yosuke, Sekiguchi Shin-Ya, Yoshida Norie, Yoshimura Tohru, Kusunoki Masami, Nakayama Toru, Nishino Tokuzo, Hemmi Hisashi
Abstract excerpt
Using FMN and a reducing agent such as NAD(P)H, type 2 isopentenyl-diphosphate isomerase catalyzes isomerization between isopentenyl diphosphate and dimethylallyl diphosphate, both of which are elemental units for the biosynthesis of highly diverse isoprenoid compounds. Although the flavin cofactor is expected to be integrally involved in catalysis, its exact role remains controversial. Here we report the crystal...
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