Article
Structural basis of free reduced flavin generation by flavin reductase from Thermus thermophilus HB8.
The Journal of biological chemistry - 23 Dec 2011
Imagawa Takahito, Tsurumura Toshiharu, Sugimoto Yasushi, Aki Kenji, Ishidoh Kazumi, Kuramitsu Seiki, Tsuge Hideaki
Abstract excerpt
Free reduced flavins are involved in a variety of biological functions. They are generated from NAD(P)H by flavin reductase via co-factor flavin bound to the enzyme. Although recent findings on the structure and function of flavin reductase provide new information about co-factor FAD and substrate NAD, there have been no reports on the substrate flavin binding site. Here we report the structure of TTHA0420 from...
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