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Bioorganometallic Chemistry with IspG and IspH: Structure, Function, and Inhibition of the [Fe 4 S 4 ] Proteins Involved in Isoprenoid Biosynthesis

31 Jan 2014

Abstract excerpt

Enzymes of the methylerythritol phosphate pathway of isoprenoid biosynthesis are attractive anti-infective drug targets. The last two enzymes of this pathway, IspG and IspH, are [Fe4 S4 ] proteins that are not produced by humans and catalyze 2 H(+) / 2 e(-) reductions with novel mechanisms. In this Review, we summarize recent advances in structural, mechanistic, and inhibitory studies of these two enzymes. In...

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PMID: 24481599
DOI: 10.1002/anie.201306712

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