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Article

Transformation of a Flavin-Free FMN Reductase to a Canonical Flavoprotein through Modification of the π-Helix.

Biochemistry - 22 Nov 2016

Musila Jonathan M, Ellis Holly R

Abstract excerpt

The flavin reductase of the alkanesulfonate monooxygenase system (SsuE) contains a conserved π-helix located at the tetramer interface that originates from the insertion of Tyr118 into helix α4 of SsuE. Although the presence of π-helices provides an evolutionary gain of function, the defined role of these discrete secondary structures remains largely unexplored. The Tyr118 residue that generated the π-helix in...

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Identifiers

PMID: 27806563
DOI: 10.1021/acs.biochem.6b00452

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