An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population.

doi:10.1038/ejhg.2008.266

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Article

An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population.

European journal of human genetics : EJHG - 1 Jul 2009

Lu Timothy Tehua, Lao Oscar, Nothnagel Michael, Junge Olaf, Freitag-Wolf Sandra, Caliebe Amke, Balascakova Miroslava, Bertranpetit Jaume, Bindoff Laurence Albert, Comas David, Holmlund Gunilla, Kouvatsi Anastasia, Macek Milan, Mollet Isabelle, Nielsen Finn, Parson Walther, Palo Jukka, Ploski Rafal, Sajantila Antti, Tagliabracci Adriano, Gether Ulrik, Werge Thomas, Rivadeneira Fernando, Hofman Albert, Uitterlinden André Gerardus, Gieger Christian, Wichmann Heinz-Erich, Ruether Andreas, Schreiber Stefan, Becker Christian, Nürnberg Peter, Nelson Matthew Roberts, Kayser Manfred, Krawczak Michael

Abstract excerpt

Genetic matching potentially provides a means to alleviate the effects of incomplete Mendelian randomization in population-based gene-disease association studies. We therefore evaluated the genetic-matched pair study design on the basis of genome-wide SNP data (309,790 markers; Affymetrix GeneChip Human Mapping 500K Array) from 2457 individuals, sampled at 23 different recruitment sites across Europe. Using...

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PMID: 19156175
DOI: 10.1038/ejhg.2008.266
PMCID: PMC2986489

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