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Article

p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2004

Jones J Shawn, Chi Xuedong, Gu Xiangjun, Lynch Patrick M, Amos Christopher I, Frazier Marsha L

Abstract excerpt

PURPOSE: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome of familial malignancies. Colorectal and endometrial cancers are most frequently observed. The syndrome results mainly from germ-line mutations in DNA mismatch repair genes. A common G-to-C polymorphism at codon 72 in the p53 gene has been associated with increased risk for lung, nasopharyngeal, oral, prostate, and breast...

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Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Genes, p53

Share to MutL Protein Homolog 1

Share to MutS Homolog 2 Protein

Share to Neoplasm Proteins

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 15355915
DOI: 10.1158/1078-0432.CCR-03-0590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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