Global and local perturbation of the tomato microRNA pathway by a trans-activated DICER-LIKE 1 mutant.

doi:10.1093/jxb/ert428

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Article

Global and local perturbation of the tomato microRNA pathway by a trans-activated DICER-LIKE 1 mutant.

Journal of experimental botany - 1 Feb 2014

Kravchik Michael, Sunkar Ramanjulu, Damodharan Subha, Stav Ran, Zohar Matat, Isaacson Tal, Arazi Tzahi

Abstract excerpt

DICER-like 1 (DCL1) is a major player in microRNA (miRNA) biogenesis and accordingly, its few known loss-of-function mutants are either lethal or display arrested development. Consequently, generation of dcl1 mutants by reverse genetics and functional analysis of DCL1 in late-developing organs are challenging. Here, these challenges were resolved through the unique use of trans-activated RNA interference. Global,...

Topics

Base Sequence
Carotenoids
Flowers
Gene Expression Regulation, Plant
Gene Silencing
Genes, Reporter
Solanum lycopersicum
MicroRNAs
Molecular Sequence Data
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plant Leaves

Plant Proteins

RNA, Plant

RNA, Small Interfering

Ribonuclease III

Seedlings

Sequence Homology, Amino Acid

Source

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Identifiers

PMID: 24376253
DOI: 10.1093/jxb/ert428
PMCID: PMC3904720

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