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Article

Global and local perturbation of the tomato microRNA pathway by a trans-activated DICER-LIKE 1 mutant.

Journal of experimental botany - 1 Feb 2014

Kravchik Michael, Sunkar Ramanjulu, Damodharan Subha, Stav Ran, Zohar Matat, Isaacson Tal, Arazi Tzahi

Abstract excerpt

DICER-like 1 (DCL1) is a major player in microRNA (miRNA) biogenesis and accordingly, its few known loss-of-function mutants are either lethal or display arrested development. Consequently, generation of dcl1 mutants by reverse genetics and functional analysis of DCL1 in late-developing organs are challenging. Here, these challenges were resolved through the unique use of trans-activated RNA interference. Global,...

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Identifiers

PMID: 24376253
DOI: 10.1093/jxb/ert428
PMCID: PMC3904720

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Source receipt: pubmed, retrieved 7 Sept 2026.

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