Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BCL11A represses HBG transcription in K562 cells.

Blood cells, molecules & diseases - 1 Jan 2000

Chen Zhiyi, Luo Hong-yuan, Steinberg Martin H, Chui David H K

Abstract excerpt

BCL11A on chromosome 2p16 was recently shown to be a major quantitative trait locus for Hb F level and F-cell number in several populations with or without beta-hemoglobinopathy. We now show that BCL11A isoforms are expressed in K562 cells. Butyrate induction of HBG globin production in K562 is associated with reduced BCL11A. Conversely, augmented expression of BCL11A in K562 cells through transfection of BCL11A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Butyrates
Share to gamma-Globins
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxamic Acids

Share to K562 Cells

Share to Mutagenesis, Site-Directed

Share to Recombinant Fusion Proteins

Share to Repressor Proteins

Source

Identifiers

PMID: 19153051
DOI: 10.1016/j.bcmd.2008.12.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BCL11A represses HBG transcription in K562 cells.PMID 19153051Read ↗

Transcriptional silencing of fetal hemoglobin by BCL11ASemantic proximity Read ↗

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.Semantic proximity Read ↗

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11ASemantic proximity Read ↗

Estimation of the difference in HbF expression due to loss of the 5' δ-globin BCL11A binding region.Semantic proximity Read ↗

BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.Semantic proximity Read ↗

BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies.Semantic proximity Read ↗

Upregulation of miR-17-3p is associated with HbF in patients with β-thalassemia and induces γ-globin expression by targeting BCL11ASemantic proximity Read ↗

An enhancer haplotype may influence BCL11A expression levels and the response to hydroxyurea in β-thalassemia patients.Semantic proximity Read ↗

KLF1 regulates BCL11A expression and γ- to β-globin gene switchingSemantic proximity Read ↗

Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin SwitchSemantic proximity Read ↗

Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobinSemantic proximity Read ↗

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.